Author: Phr. Lim
Acne is a disease of follicles.
Over production of follicular keratin leads to obstruction of the follicle with sebum and keratin. It will further lead to inflammation and proliferation of bacteria (P. acnes).
Microcomedo (white head, black head)
Accumulation of sebum and keratin forms a closed comedo (a white head). The follicular orifice is opened with continued distension, forming an open comedo (a black head). Rupture of this follicle contributes to acne.
Role of androgens
Androgens contribute to the development of acne through stimulating the growth and secretory function of sebaceous glands, increase the risk of obstruction of the follicle.